摘要
为探讨小儿何杰金淋巴瘤与EB病毒的关系,应用免疫组织化学技术及EB病毒编码的潜在膜蛋白LMP—1,对16例小儿何杰金淋巴瘤进行了检测。结果显示,12例LMP—1阳性(75%),其中混合细胞型阳性率最高,达100%,其次为结节硬化型,为80%:5岁以下、6～10岁及11～14岁三个年龄组阳性率无明显差别。本文提示,小儿何杰金淋巴瘤与EB病毒感染有较密切的关系,其中又以混合细胞型EB病毒关系最为密切。
To investigate the correlation between Epstein- Barr virus and Hodgkin's disease in children, 16 cases of Hodgkin's disease were studied by immunohistochemistry for Epstein-Barr virus (EBV) encoded latent membrane protein-1(LMP-1). LMP-1 was demonstrated 12 cases(75%). The prevalence of EBV varied between diffrent subtypes: 100% of mixed cellularity eases were found to be positive by contrast with 80% nodular sclerosis. There was no significance in LMP-1 positivity between the different age groups, these results indicated that Hodgkin's disease was strongly linked to EBV. Mixed cellularity subtype of Hodgkin's disease had the strongest association with EBV among all subtypes.
