胰高糖素—胰岛素疗法治疗重症肝炎的探讨

Glucagon-insulin therapy in severe hepatitis

通过对１０８例病毒性肝炎患者的空腹血糖（Ｇｌｕ），胰岛素（Ｉｎｓ），胰高糖素（Ｇｌ）的检测，探讨胰高糖素—胰岛素疗法（Ｇ—Ｉ疗法）对重症肝炎的治疗意义。结果：重症肝炎组的Ｇｌｕ４．４１±０．９６ｍｍｏｌ／Ｌ，Ｉｎｓ：１３．９１±３．２５ｍｕ／Ｌ，Ｇｌ：４８２．５６±１５８．６４ｎｇ／Ｌ，与正常人对照Ｐ＜０．０１。三者之间调节紊乱，普通型肝炎则无影响。结果提示在重症肝炎中应用Ｇ—Ｉ疗法是不恰当的。

In order to assess the effect of glucagon-insulin therapy(GIT) in severe hepatitis,the concentrations of fasting blood glucose(Glu),serum insulin(Ins) and glucagon(GL) were detected in 108 patients with viral heapatitis.In the group of severe hepatitis,the level of Glu,Ins and GL were 4.41±0.96 mmol/L,13.91±3.25 mμ/L,and 482.56±158.64 ng/L,respectively.These were significantly higher than those in the normal controls( P <0.01),but there was no significant difference in the mild hepatitis.The results suggests that GIT may be an inadvisable therapy for severe hepatitis.