老年结直肠癌患者血清sIL-2R水平测定与临床意义的研究

Determination and clinical evaluation of serum soluble IL-2 receptor in old patients with colorectal carcinoma

老年结直肠癌患者血清ｓＩＬ－２Ｒ水平测定与临床意义的研究第四军医大学唐都医院普外科张力，吴金生（西安７１００３８）摘要＇ｅｍ应用双抗体夹心ＥＬＩＳＡ法，对３８例老年人（６５～８０岁）结直肠癌患者血清可溶性白细胞介素２受体（ｓＩＬ－２Ｒ）进行测定，结果...

The serum soluble interleukin - 2 receptor (slL - 2R ) in 38 old patients with colorectal carcinoma was determined by using sandwich ELISA with monoclonal and polyclonal antibodies technique,The results showed that (1) the sIL- 2R level was significantly higher than that in the control (P<0. 01 ). (2)the sIL--2R level in patients at stages C , D according to Dukes'classificqtion was higher than that in the patients at stages A,B (P<0. 05 ). (3)the sIL - 2R level of the effectively treated group decreased significanty,but that in the ineffetive group continued on high level 6 months after operation and chemotherapy,Therefore,defermination of sIL-2R level in serum has great referential value not only for diagnosis and judgement of advancing condition but also for evaluation of clinical stages and therapeutic effi- cacy in old patients with colorectal carcinoma.