摘要
为探讨α－２ａ－干扰素治疗血管瘤的作用机制，采用新鲜皮肤血管瘤组织进行血管内皮细胞组织块培养并传代，通过加入α－２ａ－干扰素，观察其对血管内皮细胞增殖的影响。结果：当α一２ａ一干扰素应用剂量为５ｘ１０ｔｕ／Ｌ和１×１０ｔｕ／Ｌ时，对血管内皮细胞的增殖有明显抑制作用。应用：５×１０ｕ／Ｌ，培养第１２ｄ后，血管内皮细胞数量和３Ｈ．ＴｄＲ掺入量明显低于对照组。结论：α－２ａ－干扰素可能是通过抑制血管瘤血管内皮细胞的增殖，促进血管瘤的退化而发挥治疗作用。
This study was aimed to elucidate the mechanism of effect of alpha - 2 a - interferon on hemangiomas. Endothelial cells (ECs ) of hemangiomas were cultured and subcultured by tissue culture method. With addition of alpha - 2 a -interferon , its effect on the growth of ECs was observed. The results showed that. alpha -2 a-interferon (5 X L05 u/L , 1 X 10 u/L) had significant inhibitory effects on proliferation of ECs. In the alpha - 2 a -interferon treated group (5 X 10 u/L) ,EC counts and 3H-TdR incorporation were lower than those in the control group at the 12th day. It is suggested that the alpha-2 a -interferon cures the hemangiomas by inhibiting the growth of ECs of them.
出处
《武警医学》
CAS
1997年第5期249-251,共3页
Medical Journal of the Chinese People's Armed Police Force
