转录因子Foxp3与肿瘤免疫及其调控

The role of Foxp3 and its immunoregulation mechanism in turhor immunity

Foxp3高表达于CD4^＋CD25^＋调节性T细胞（CD4^＋CD25^＋Tr），与其分化、发育和免疫调节功能关系密切。较为普遍的观点认为Foxp3是Tr的一个特征性分子标志。而新近的研究提出，Foxp3不仅仅表达于Tr细胞，并有人提出表面分子标志CD127才是调节性T细胞的特异性标志，争论的结果有待进一步证实。近年，Foxp3对Tr的发生、发育及免疫功能的影响已逐渐成为免疫学研究热点，Foxp3与肿瘤免疫调节的关系越来越被广泛关注，机体对Foxp3的不同的调控机制成为学者讨论的焦点，但Foxp3的确切调节机制还有待进一步深入研究。

Foxp3 is highly expressed in CD4^＋ CD25 ^＋ regulatory T cells, and play a critical role in their differentiation, development, and immunoregulation function. It is widely believed that Foxp3 is a specific factor of CD4 ^＋ CD25 ^＋ regulatory T cells, but the recently researchers have argued that Foxp3 expresses not only on CD4 ^＋ CD25 ^＋ regulatory T cells, but also proved that CD127 was the specific cell surface factor indeed. Further evidence is in need to end the discussion. The role of Foxp3 in the differentiation, development, and immunoregulation function of CD4 ^＋ CD25 ^＋ regulatory T cells has become a hot point. A growing number of researchers have focused on its effect in tumor immunity, and there drastic debates on its regulation mechanism.