期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

单核细胞表面CD86分子的研究进展

The progress of CD86 on the surface of monocyte
原文传递
导出
摘要 共刺激分子在抗原递呈中起着重要的作用，CD86则是非常重要的共刺激分子，它与配体CD28和CTLA-4相结合后，能够产生重要的免疫学效应。CD86的升高和降低受多种因素影响。CD86的升高与降低在临床上也具有重要的意义，并且和疾病的预后相关。对于自身免疫性疾病而言，对CD86信号的调节，也提供了合理的有效的调节免疫系统的途径。 Costimulatory molecules have important functions on antigen presentation. CD86 is one of important costimulatory molecules. Binding with its ligands such as CD28 and CTLA-4, CD86 can lead to various crucial immune effects. The level of CD86 is influenced by many factors, and is related to the patients＇ prognosis. For patients with autoimmune diseases, the manipulation of CD86 signals represents a rational and effective approach to modulating the immune system activation.
作者 张毅 陆丽华
机构地区 上海长海医院烧伤科
出处 《国际免疫学杂志》 CAS 2008年第6期474-478,共5页 International Journal of Immunology
关键词 单核细胞 CD86 共刺激分子 Monocyte CD86 Costimulatory molecule
分类号 R3 [医药卫生—基础医学]
  • 相关文献

参考文献28

  • 1Crow MK. Modification of accessory molecule signaling Springer Semin Immun opatho1,2006,27 (4) :409-424
  • 2Wang S, Chen L. T lymphocyte co-signaling pathways of the B7- CD28 family. Cell Mol Immuno1,20(M, 1 ( 1 ) : 3742.
  • 3Mukherjee, S, Ahmed, A, Malu set al. Modulation of cell cycle progression by CTLA4-CDS0/CD86 interactions on CD4 ^+ T cells depends on strength of the CD3 signal: critical role for IL-2. J Leukoc Biol,2006 ,80( 1 ) :66-74
  • 4Manzotti CN, Liu MK Burke F, et al. Interaction of CTLA-4(CD152) with CD80 or CD86 inhibits human T-cell activation. Eur J Immunol,2006,36 (6) : 1413-1422.
  • 5David M. Sansom, Claire N, et al. What' s the difference betweenCD80 and CD86? TRENDS in Immunology , 2003,24 ( 6 ) : 313-318
  • 6Yoshimura S, Bondeson J, Foxweu BM et al. Effective antigen presentation by dendritic cells is NF-kappaB dependent coordinate regulation of MHC, co-stimulatory molecules and cytokines. IntImmunol, 2001,13 (5) :675-683
  • 7Lanier LL, O′Fallon S, Somoza C,et al. CD80 (137) and CD86 (1370) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL. J Immunol,1995 ,154 ( 1 ) :97-105
  • 8Punt JA, Roberts JL, Kearse KP, et al. Stoichiometry of the T cell antigen receptor (TCR) complex: each TCR/CD3 complex contains one TCR alpha, one TCR beta, and two CD3 epsilon chains. J Exp, 1994,180(2) :587-593
  • 9Larsen CP, Knechtle SJ, Adams A, et al. A new look at blockade of Tcell costimulation: A therapeutic strategy for long-term maintenance Immunosuppression: Am J Transplant, 2006,6 ( 5 Ptl ) : 876-883
  • 10Ganea D, Delgado M. Neuropeptides as modulators of macrophage functions. Regulation of cytokine production and antigen presentation by VIP and PACAP . Arch Immunol Ther Exp ( Warsz ), 2001,49(2) :101-110.
国际免疫学杂志
2008年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部