摘要
转化生长因子-β(TGF-β)超家族在胚胎发育和细胞的分化中具有多方面的生理功能,调控基因十分广泛。Smads蛋白是TGF-β超家族表达细胞内重要的信号转导和调控分子。多种DNA结合蛋白可以与Smads结合,直接影响其所调控基因的差异。Smads蛋白在DNA共结合因子辅助下,招募转录激活因子或转录抑制因子调控靶基因的转录。
Transforming growth factor-β(TGF-β) superfamily have versatile physiological functions in the embryonic development and cell differentiation, and can widely regulate gene expressions. Smads protein is a important molecule of signal transduction and regulation in the TGF-β superfamily expression cells. Several DNA- binding proteins can bind to Smads,which directly impact their differences of regulating gene. Smads protein is under the assistance of DNA binding factor , recruiting activating transcription factors or transcription inhibition factors to regulating transduction of target gene.
出处
《国际免疫学杂志》
CAS
2008年第6期482-485,共4页
International Journal of Immunology
关键词
转化生长因子-Β
SMADS蛋白
信号转导
转录调节因子
Transforming growth factor-β, Smads protein
Signal transduction
Transcription regulation factors