血必净注射液在急性重度百草枯中毒中的应用

Effects of Xuebijing Injection on Acute Severe Parquat Poisoning

目的:评价血必净注射液治疗急性百草枯中毒的临床疗效。方法:选择我院重症监护室2002年1月～2008年4月收治的急性重度百草枯中毒患者35例为研究对象,分为血必净治疗组(n=20)与对照组(n=15),血必净治疗组在对照组的基础上应用血必净注射液100mL,每日2次,7～10d为1个疗程。结果:2组治疗后肝酶和血肌酐均明显下降,血必净治疗组显著低于对照组(P<0.05);1周后血必净治疗组的氧分压明显高于对照组(P<0.05);血必净治疗组的死亡率明显低于对照组(P<0.05)。结论:早期应用血必净可减轻百草枯对重要脏器的损害,降低百草枯中毒的病死率。

OBJECTIVE： To evaluate the clinical efficacy of Xuebijing injection in treating acute paraquat poisoning. METHODS： 35 patients with acute severe parquat poisoning who were admitted into ICU of our hospital from Jan. 2002 to Apr. 2008 were enrolled in our study： 15 cases were assigned to control group, 20 （treatment group） received Xuebijing 100 mL bid for 7-10 d in addition to the therapy as in control group. RESULTS： Liver enzyme and creatinine levels in both group were reduced, with the level in the treatment group significantly lower than in control group （P 〈 0.05）. The oxygen pressure after one week was significantly higher in treatment group than in control group （P 〈 0.05） . The mortality was also significantly lower in treatment group than in control group （P 〈 0.05）. CONCLUSION： Early application of Xuebijing injection can protect major organs from injury induced by parquat and reduce the mortality of parqaut poisoning.