儿童过敏性紫癜血小板参数及纤维蛋白原含量变化

Clinical significance of thrombocyte parameter and fibrinogen in Henoch-Schonlein purpura

目的探讨各型儿童过敏性紫癜(HSP)患者急性期血小板参数及纤维蛋白原含量的变化及临床意义。方法回顾性分析70例HSP患儿红细胞比容(HCT)、血小板计数(BPC)、血小板分布宽度(PDW)、大血小板比率(P-LCR)及纤维蛋白原含量(FIB),并进行统计学比较分析。结果腹型、混合型及肾型HSP患儿FIB较单纯型明显升高(P<0.05);但HCT、BPC、PDW及P-LCR,各组间差异无显著性。HSPN重型(急性肾炎型,肾病综合征型)PDW、P-LCR及FIB明显高于轻型(孤立性蛋白尿或血尿者,血尿伴蛋白尿者)(P<0.01),而HCT、BPC两组间差异无显著性。结论HCT及BPC不宜单独用于HSP患儿高凝状态及病情演变的判断;PDW、P-LCR及FIB较有价值(尤对HSPN患儿),对其进行动态监测,以判断体内凝血系统状态、推测HSPN病情轻重、指导临床用药具有积极意义。

Objective To explore clinical significance of thrombocyte parameter,contents of fibrinogen in acute stage of Henoch-Schonlein purpura（HSP）.Methods Seventy patients with HSP were studied using retrospective analysis.Erythrocrit（HCT）、blood platelets count（BPC）、platelet distribution width（PDW）、proportion of big platelet（P-LCR）and contents of fibrinogen（FIB）were compared in each group.Results Contents of FIB in patients with gastrointestinal involvement,renal involvement and mixed pattern were obviously higher when compared with patients with simple cutaneous lesion.There were no significant distinctations found during each group about HCT,BPC,P-LCR and PDW.But the distinctations of PDW,P-LCR and FIB between gravis type and levis type of HSPN were remarkable.No marked changes were observed of HCT and BPC.Conclusions HCT and BPC are not suitable to be used alone as criterions of judgement of hypercoagulabale state and development of pathogenetic condition.PDW,P-LCR and FIB are more valuable relatively and could be monitored dynamicly to estimate the state of blood coagulation,conjecture the light and heavy press of pathogenetic condition,guid clinical medication,especially in patients with HSPN.