摘要
目的应用16层螺旋CT扫描观察慢性阻塞性肺疾病(COPD)患者肺衰减值与肺功能检查结果的相关关系。方法COPD患者共50例,均行16层螺旋CT检查和肺功能检查。通过直方图技术测量全肺平均衰减值(MLA)、小于-910 HU和小于-950 HU阈值的像素指数(PI_(-910)、PI_(-950)),评估MLA、PI_(-910)及PI_(-950)与肺功能检查结果间的相关关系,并比较COPD 0～4级组间MLA、PI_(-910)及PI_(-950)的组间差异。结果MLA、PI_(-910)及PI_(-950)与肺功能指标间均存在相关关系,与反映存在气流受限的指标FEV 1%FVC(%)相关关系最强,PI_(-950)与肺功能检查结果间的相关关系较MLA、PI_(-910)强。PI_(-950)较MLA、PI_(-910)更能反映组间差异。结论CT定量研究COPD肺衰减值可对患者肺实质改变进行全肺三维立体评估。PI_(-950)可作为CT定量评估COPD患者肺实质改变较敏感的指标。
Objective To investigate the relationship between lung attenuation and pulmonary function test （PFT） results in patients with COPD using 16 slice spiral CT （16-SCT）. Methods Fifty COPD patients underwent 16-SCT and PFT. Quantitative analysis was performed with histograms, and the mean lung attenuation （MLA）, the pixel index （PI） of the proportions of lung volumes with attention values below -910 HU and -950 HU were measured. The correlations between MSCT measurements and PFT results were assessed, and differences of MLA, PI-910 and PI-950 among the groups of the pa tients with COPD from stage 0-4 were evaluated. Results MLA, PI-910 and PI-950 were significantly correlated with PFT resuits. MLA, PI-910 and PI-950 correlated the most closely with FEV1/FVC（%） which reflected airflow limitation and obstruction. PI-950 correlated closely with PFT results. Among the groups from stage 0-4, PI-950 reflected differences more sensitively than MLA and PI-910. Conclusion Quantitative MSCT study of lung attenuation can assess the changes of pulmonary parenchyma in patients with COPD by three-dimensional analysis. PI-950 is a rather sensitive index in quantitative study of pulmonary parenchymal changes in patients with COPD.
出处
《中国医学影像技术》
CSCD
北大核心
2008年第10期1611-1614,共4页
Chinese Journal of Medical Imaging Technology
