冠心病并代谢综合征患者血清糖基化终末产物的水平及其临床意义

Clinical significance of serum advanced glycation end products in coronary artery disease patients with metabolic syndrome

目的:研究冠心病并代谢综合征(MS)患者血清糖基化终末产物(AGE)含量的变化及其临床意义。方法:选择单纯MS患者(A组)32例,单纯冠心病患者(B组)36例,冠心病并MS患者(C组)39例和正常对照(D组)28例。对所有受试者测量其身高、体重、腰围(WC)、臀围(HC);测血脂、空腹血糖(FBG)、胰岛素(FIN)、AGE;计算体质指数(BMI)、腰臀比(WHR)、胰岛素抵抗指数(HOMA-IR)并进行比较。结果:A、B、C组患者的FIN、HOMA-IR、AGE均高于D组,C组的HOMA-IR、AGE分别高于A、B组。直线相关分析显示,HOMA-IR与BMI、WC、TG、FBG、FIN和AGE呈正相关,与HDL呈负相关。结论:冠心病并MS患者AGE的表达异常升高。

Objective：To investigate the level and clinical significance of surum advanced glycation end products （AGE） in coronary artery disease patients with metabolic syndrome （MS）. Method： We selected 32 patients with simple MS （group A）, 36 patients with coronary disease （group B）, 39 patients with coronary heart disease combined with MS （group C） and 28 normal subjects （group D）. All subjects received detection of height, weight, waist circumference, hip circumference, BMI, WHR, blood lipid, fasting blood glucose, fasting insulin （FIN） and AGE. The degree of insulin resistance was assessed by the homeostasis model assessment insulin resistance index （HOMA IR）. Result：Compared with group D, the levels of FIN, HOMA- IR, AGE in the group A, ]3 and C increased significantly. The levels of HOMA-IR and AGE were higher in group C than in group A and B. HOMA- IR was positively correlated with BMI, waist circumference, WHR, fasting blood glucose, FIN, TG, AGE and negatively with HDL. Conclusion： Serum AGE increases in patients with coronary artery disease combined with MS.