小细胞肺癌患者抑郁状态与Th1/Th2型细胞因子相关性的初步研究

Relationship Between Depression and Serum Levels of Th1/Th2 Cytokines from Patients with Small Cell Lung Cancer

目的:探讨小细胞肺癌患者抑郁状态与辅助性T细胞(Th)1/Th2型细胞因子之间的关系。方法:选择小细胞肺癌患者91例,按照汉密尔顿抑郁量表(HAMD)评分标准分为抑郁组41例和无抑郁组50例,并设立健康对照组。用酶联免疫吸附法(ELISA)检测患者外周血中Th1型细胞因子白细胞介素2(IL-2)、干扰素γ(IFN-γ)和Th2型细胞因子白细胞介素4(IL-4)、白细胞介素10(IL-10)的浓度。结果:小细胞肺癌患者外周血中IL-2、IFN-γ水平较健康组明显下降,IL-4I、L-10水平较健康组显著升高。而与无抑郁组比较,抑郁组外周血中IL-2、IFN-γ水平下降更为明显,IL-4I、L-10水平升高更为显著。结论:小细胞肺癌患者外周血中的Th1/Th2型细胞因子明显失衡,细胞免疫功能低下,尤其是伴有抑郁障碍者细胞免疫功能低下更为显著。因此,尽早识别和治疗小细胞肺癌伴抑郁障碍者具有重要意义。

Objective. To investigate the relationship between the depression and the levels of Th1/Th2 cyto- kines in serum from patients with small cell lung cancer. Methods. Ninety-one patients with small cell lung cancer were divided into depression group （n=41） and nowdepression group （n=50） according to the Hamilton depression scale（HAMD）. The interleukin-2 （IL-2）, interferon-γ（IFN-γ）, interleukin 4 （IL-4） and interleukin 10 （IL-10） in serum were determined by enzymeqinked immunosorbent assay （ELISA）. Results. Compared with that of healthy control group and the non-depression group, the levels of IL-2 and IFN-γ in serum from patients of depression group were decreased significantly, and the levels of IL-4 and IL-10 were increased significantly. Compared with that of non-depression group, the levels of IL-2 and IFN-γ in serum from the patients of depression group were decreased more significant- ly, the levels of IL-4 and IL-10 were more significantly increased. ConclusionThe levels of Th1/Th2 cytokines in serum from the patients of depression group are more significantly imbalanced than that of non-depression group. It is very important for us to diagnose and to treat the depression of patients with small cell lung cancer as early as possible.