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巨块型ⅠB、ⅡA期宫颈癌术前放化疗224例临床分析 被引量：2

The efficacy of preoperative chemoradiation for 224 cases of bulky stage ⅠB、ⅡA cervical cancer
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摘要 目的:探讨新辅助化疗对巨块型ⅠB、ⅡA期宫颈癌的近期疗效和预后影响。方法:回顾性分析了224例新辅助化疗配合腔内后装放疗(治疗组)及100例单独腔内后装放疗(对照组)后再行手术的巨块型ⅠB、ⅡA期宫颈癌的近期疗效和远期疗效。结果:对照组总有效率84.0%,5年生存率60.0%;治疗组总有效率91.1%,5年生存率为68.0%,两组总有效率和5年生存率的差异显著(P<0.05)。治疗组中新辅助化疗的方案对近期疗效无影响(P>0.05)。结论:巨块型ⅠB、ⅡA期宫颈癌术前行新辅助化疗配合腔内后装放射治疗,可能是更好的治疗选择。 Objective：To explore the efficacy of neoadjuvant chemotherapy（NAC） in bulky stage ⅠB and stage ⅡA cervical cancer.Methods：We retrospectively analyzed 224 cases of bulky stage ⅠB and stage ⅡA cervical cancer patients（treatment group） who received NAC and after-loading radiotherapy before operation,and 100 patients（control group） who received after-loading radiotherapy only before operation.Results：NAC combined with after-loading radiotherapy can achieve higher total effective rate（91.1%） and 5-year survival rate（68.0%） than those（84.0%,60.0%） of after-loading radiotherapy only before operation（P〈0.05）.The regimen of NAC has no influence on the effective rate in our study（P〉0.05）.Conclusion：The bulky stage ⅠB and stage ⅡA cervical cancer patients received NAC and after-loading radiotherapy before operation was an effective selection.
作者 仇龙山 彭素蓉
机构地区 建湖县人民医院妇科 江苏省肿瘤医院妇瘤科
出处 《临床肿瘤学杂志》 CAS 2008年第10期911-913,共3页 Chinese Clinical Oncology
关键词 宫颈癌 新辅助化疗 后装放疗 Cervical cancer Neoadjuvant chemotherapy（NAC） After-loading radiotherapy
分类号 R737.33 [医药卫生—肿瘤]
  • 相关文献

参考文献8

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二级参考文献33

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共引文献5

同被引文献17

  • 1章文华,吴令英,白萍,李淑敏,张蓉,李斌,孙建衡,吴爱如.ⅠB期和ⅡA期宫颈癌患者的预后因素分析[J].中华肿瘤杂志,2004,26(8):490-492. 被引量：41
  • 2白惠娟,李秀荣,陈红敏.新辅助化疗治疗巨块型宫颈癌疗效观察[J].中国肿瘤临床与康复,2005,12(4):367-367. 被引量：6
  • 3Toita T, Mitsuhashi N, Teshirna T, et al. Postoperative radiotherapy for uterine cervical cancer: results of the 1995- 1997 patterns of care process survey in lapan[J]. Clin Oncol, 2004,34 (2) : 99-103.
  • 4Rutledge TL, Kamelle SA, Tillmanns TD, et al. A com- parison of stage Ⅰ b1 and Ⅰ b2 cervical cancers treated with radical hysterectomy: is size the real difference[J]. Gyneeol Oncol, 2004,95 (1) : 70-76.
  • 5Havrilesky LJ, Leath CA, Huh W, et al. Radical hyster- ectomy and pelvic lymphadenectomy for stage I b2 cervical cancer[J]. Gynecol Oncol,2004,93(2):429-434.
  • 6FIGO Committee on Gynecology Oneology. Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium [J]. Int J Gynecol Obstet, 2009,105 (2) : 103-104.
  • 7Cai HB,Chen HZ, Yin HH. Randomized study of preopera- tive chemotherapy versus primary surgery for stage Ⅰ b cervi- cal caneer[J]. J Obstet Gynecol Res, 2006,32(3) : 315-323.
  • 8Sardi JE, Boixadera MA, Sardi JJ. Neoadjuvant chemotherapy in cervical cancer:a new trend[J]. Curt Opin Obstet Cynecol, 2005,17(1) :43-47.
  • 9熊樱,粱立治,郑敏,王銮红,邓鹏飞,刘继红.子宫颈癌伴盆腔淋巴结转移患者的复发及预后分析[J].中华妇产科杂志,2008,43(6):425-428. 被引量：17
  • 10冯文,房瑜,黎群,蔡明,杨成喜.术前新辅助化疗治疗局部中晚期宫颈癌的临床初步观察[J].肿瘤基础与临床,2008,21(6):492-494. 被引量：4

引证文献2

二级引证文献6

临床肿瘤学杂志
2008年 第10期

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