咽部多形性腺瘤临床病理观察及文献复习

Pharyngeal plemorphic adenoma:a clinicopathological observation and literaturesre view

目的:探讨咽部多形性腺瘤(PA)的形态学及免疫组化表型特征。方法:对1例咽部PA进行临床病理分析和免疫组织化学研究,并结合文献分析其对鉴别诊断的意义。结果:咽部PA由上皮、肌上皮及粘液样、软骨样或透明变样间叶成分组成;免疫组化染色示:CK7(+),CK20(-),S-100(+),GFAP(+),CD57(+),p63(+)。结论:咽部PA是一种起源于小涎腺的良性肿瘤,其独特的病理学特征和免疫表型特点,对其鉴别诊断有重要意义。

Objective：To study the clinicopathological and immunophenotype features of pharyngeal plemorphic adenoma（PA）.Methods：One case of typical pharyngeal PA was examined by light microscopy and immunohistochemistry,and the significance of its clinicopathological and immunophenotype features,which was also analyzed under the review of literatures.Results：Pharyngeal PA consisted of epithelial,modified myoepithelial,mucoid,myxoid and chondroid elements.Immunohistochemical study demonstrated the tumour cells were characterized as CK7（＋）,CK20（-）,S-100（＋）,GFAP（＋）,CD57（＋） and p63（＋）.Conclusion：Pharyngeal PA is one of benign tumours occurred predominantly in the minor salivary gland.Its clinicopathological and immunophenotype features have an important role in differential diagnosis of pharyngeal PA.