120例矽肺结核患者结核分枝杆菌L型致病情况研究

Mycobacterium tuberculosis L forms in 120 patients with pulmonary silicotuberculosis

目的探讨研究120例矽肺结核患者结核分枝杆菌L型致病情况的价值。方法对矽肺结核组和矽肺患者,分别进行痰结核分枝杆菌和痰结核分枝杆菌L型培养,并对结果进行对照观察。结果矽肺结核120例痰结核分枝杆菌培养阳性14例,阳性率11.6%,同时出现结核分枝杆菌L型培养阳性10例,占71.4%;痰结核分枝杆菌L型培养阳性58例,阳性率48%(P<0.01)。结论结核分枝杆菌L型培养方法方便快速,能提高结核分枝杆菌的检出率,对矽肺结核的早期诊断及减少矽肺结核复发的漏、误诊有肯定的价值。

Objective To evaluate significance of Mycobacterium tuberculosis L forms in pathogenesis of silicotuberculosis and silicosis. Methods Sputum culture for Mycobacterium tuberculosis and its L forms was conducted from both silicotuberculosis and silicosis groups, and the results were compared. Results Among 120 silicotuberculosis patients, 14 （11.6% ） were sputum Mycobacterium tuber-culosis culture positive, of which 14 （71. 4% ） were Mycobacterium tuberculusis L forms culture positive,58 were sputum Mycobacterium tuberculosis L forms culture positive with a positive rate of 48% （ P 〈 0. 01 ）. Conclusion Sputum culture for Mycobacterium tuberculosis L forms is a convenient and rapid way to improve the detection rate of Mycobacterium tuberculosis,with a positive value in the early diagnosis of silieotuberculosis by reducing its misdiagnosis and missed diagnosis. Detection rate of Mycobacterium tuberculosis L forms significantly increases with deterioration of silicosis.