动态血压多变量与原发性高血压左室重构的关系

Relationship between ambulatory blood pressure multi-parameters and left ventricular remodeling in patients with essential hypertension

目的:利用动态血压监测技术分析其变量与原发性高血压患者左室重构的关系.方法:选择1级、2级原发性高血压病患者138例进行动态血压及超声心动图检查,依据左室构型将高血压病患者分为4组:正常左室构型组,向心性重构组,向心性肥厚组和离心性肥厚组.对4组的动态血压各项指标进行统计学方差分析.结果:4组间收缩压各项指标均有统计学差异(P<0.05):第3组与第4组的24h平均收缩压(24hSBp)、夜间平均收缩压(nSBp)和收缩压负荷(SBp负荷)值均较第1组和第2组高,第3组的白昼平均收缩压(dSBp)较其他3组高;在舒张压指标方面:第3组与第4组的夜间舒张压较第1组和第2组高,其余舒张压指标无统计学差异.结论:收缩压水平是高血压左室构型改变的重要危险因素.

AIM： To explore the relationship between left ventricular remodeling （LVR） and ambulatory blood pressure multiparameters in patients with essential hypertension. METHODS： 138 patients with grade Ⅰ or Ⅱ essential hypertension were divided into 4 groups based on Ganau Criteria： normal ventricular configuration, centrality remodeling group, concentric hypertrophy group, and eccentric hypertrophy group. Ambulatory blood pressure multi-parameters were determined with the use of statistical analysis. RESULTS： There were differences in the indices of systolic pressure between the 4 groups. 24 h SBp, nSBp, and dSBp were higher in group 1, 2 than in group 3, d. dSBp was higher in group 3 than in group 1 , 2, 4. There were differences in diastolic pressure at night between group 1,2 and group 3, 4. No significant difference in other indices of diastolic pressure was observed. CONCLUSION： Indices of systolic pressure are risk factors in left ventricle remodeling.