发展性照顾促进早产儿血中胃动素胃泌素水平变化的研究

The research on changes in motilin and gastrin levels of premature infants＇ blood under developing care

目的对早产儿实施发展性照顾，了解发展性照顾对早产儿血中胃动素胃泌素分泌的影响。方法利用随机数字表进行随机化分组，对照组45例采用早产儿常规护理方法，观察组45例采用发展性照顾护理措施。采用放射免疫法测定早产儿血中胃动素（MOT）及胃泌素（GAS）的变化。结果MOT在出生后第3天对照组（194．19±54．95）ng／L，观察组（227．43±85．98）ng／L；第10天对照组（266．00±71．98）ng／L，观察组（293．42±52．02）ng／L；GAS第3天对照组（57．64±18．11）ng／L，观察组（73．88±35．90）ng／L；第10天对照组（68．25±23．53）ng／L，观察组（79．46±24．50）ng／L，差异均有统计学意义（P〈0．05）。结论运用发展性照顾护理措施，能促进早产儿血中胃肠激素的释放，促进消化功能早期建立和进一步发育成熟，可增加胃肠道局部抗氧化功能，对早产儿幼嫩的肠黏膜有一定保护作用。

Objective To give premature infants developing care and collect the information of the developing care＇ s influence on secretion of motilin and gastrin of premature infants＇ blood. Methods The newborn patients were divided into the control group and the observation group at random using the random number table. 45 cases in the control group used the premature infants conventional care. 45 cases in the observation group adopted the developing care. We used the radioimmunological analysis （RIA） to determine the changes of motilin （MOT） and gastrin （GAS） of premature infants＇ blood. Results The values of MOT in the third day were （194.19 ±54.95）ng/L in the control group and （227.43 ±85.98）ng/L in the observation group, with P value of 0.032; those in the 10th day were （266. 00 ±71.98） ng/L in the control group and （293.42±2. 02） ng/L in the observation group, witla P value of 0.041. The differences were significant （P 〈 0. 05）. The values of GAS in the third day were （57.64 ± 18.11 ） ng/L in the control group and （ 73.88 ± 35.90） ng/L in the observation group, with P value of 0.009 ; those in the 10th day were （68.25 ± 23.53 ） ng/L in the control group and （79.46 ± 24.50） ng/L in the observation group, with P value of 0. 029. The differences were significant （ P 〈 0. 05 ）. Conclusions The developing care methods can promote the release of gastrointestinal hormone in premature infants ＇ blood, promote the early establishment and further development and mature of digestion functions, and increase the antioxidation function of certain parts of gastrointestinal tract, whereby protecting the intestinal mucosa of new iv：rants to a certain extent.