原发性震颤三家系分析

Analysis of three family with essential tremor

目的探讨原发性震颤的临床表现、家系特点及治疗。方法对3例原发性震颤患者的临床特点和家族史进行分析。结果ET在同一家族中男女均可发病,3例先证者一级、二级亲属患病率分别为:41.2%、40.0%和50.0%。结论原发性震颤是具有家族遗传性的疾病,以姿势性或意向性震颤为主,手及头部受累明显,多数患者饮酒试验阳性,β受体阻滞剂普奈洛尔治疗有效。

Objective To investigate the clinical manifestation, familial characteristics and treat ment of essential tremor （ET）. Methods Three ET patients were reviewed and their clinical features and familial history were analyzed. Results Both males and females in a family could suffer ET. The incidence rates of first--degree and second degree relatives in the three families were 41.2 %, 40.0%and 50.0%, respectively. Conclusions ET is assumed to be genetic disease. The main clinical characteristic of essential tremor is postural or intentional tremor. Tremor mostly involves in hands and head. Positive result of alcohol test is shown in most patients. The treatment with Propranolol, an β-adrenoceptor an- tagonist is effective.