摘要
2,3-二氯吡啶是新型杀虫剂氯虫苯甲酰胺的关键中间体。比较了2,3-二氯吡啶的各种合成方法,探索了一条以3-氨基吡啶为原料,经过氯化、重氮化和sandmeyer反应,中间体不分离,一锅法合成2,3-二氯吡啶的经济合理的路线,收率66.9%,含量98%以上。对反应的机理进行了探讨,对副产物进行了分离与表征。
2,3-Dichloropyridine is a key intermediate of a new insecticide chlorantraniliprole. Several synthesis routes of 2,3-dichloropyridine were evaluated in this paper, and therefore an economic and reasonable one-pot synthesis of 2,3-dichloropyridine was explored through chlorination, diazotization and sandmeyer reaction starting with 3-aminopyridine yield and purity of the product was 66.9% and 98% respectively. In additions of the mechanisms of reactions were studied and the by-products were separated and characterized.
出处
《精细化工中间体》
CAS
2008年第5期19-21,45,共4页
Fine Chemical Intermediates
关键词
2
3-二氯吡啶
氯虫苯甲酰胺
一锅法
合成机理
2,3-dichloropyridine
chlorantraniliprole
one-pot synthesis
mechanism of synthesis
