大鼠侧脑室及鞘内注射孤啡肽减弱苏太尼镇痛效应

Intrathecal or intracerebroventricular administration of OFQ attenuates fentanyl analgesia on rats

目的进一步阐明孤啡吠在痛觉调制中的作用。方法；本实验在大鼠电刺激甩尾测痛模型上．观察了侧脑室（icu）及路内（it）注射孤啡肽对芬太尼镇痛效应的影响。结果：icu及it注射孤啡吠后可减弱芬太尼镇痛效应。结论：孤啡肽的致痛敏作用可能与其对抗由μ受体介导的痛抑制效应有关。

To study thmechanisms of OFQ in pain modulation. METHODS: OFQ orfentanyl was microinjected into the lateral ventrical or the spinal subarachnoid space of rats.the pain threshold was measured using tail-flicktest' RESULTS: Intrathecal orintracerebroventricular administration of OFQ significantly reduced fentanyl analgesia. CONCLUSION:OFQ may play its hyperanalgesic role viaattenuating the μ-receptor mediated inhibition onpain transmission.