bcl-2蛋白在胃癌组织中的表达和意义

Expression of bcl-2 Protein in Gastric Carcinomas

应用免疫组织化学技术，观察胃癌组织中bcl-2表达，探讨其临床病理意义。结果显示，bcl-2表达的阳性率为82％，阳性反应物质位于细胞浆或极膜上，胞核中偶有表达。bcl-2在胃癌组织中的表达与病人年龄、性别、肿瘤大小、淋巴结转移、浆膜情况及临床分期无明显关系（P＞0．05）。与胃癌形态学分型及分化程度有明显关系（P＜0．01）。提示bcl－2异常表达与肠型胃癌发生的关系密切，bcl－2在胃癌形成的早期阶段及表型分化中起重要作用，而在胃癌中晚期的作用不明显。

In order to further study the role of bcl-2protein in gastric carcinogenesis and tumor progression, an immunohistochemical study of bcl-2 protein expression in 50 cases of gastric carcinoma and its relation to clinical status, pathomorphological parameters was performed. Results showed: 41 cases (82% ) were positive for bcl-2 proteinstaining which was localized in the cytoplasm and nuclear membrance of tumor cells. The rate of bcl-2 protein expression had no correlation to the age of patients, sex, tumor size, lymph node status, clinical stage (P>0.05 for each). It was strongly associated with intestinal-type tumors and poorly differentiated tumors. Our results suggest that bcl-2 protein expression appears to be specifically associated with development of intestinal-type gastric carcinoma, bcl-2 protein expression might play a role of in the early development/promotion and phenotypic differentiation of gastric carcinomas but not in tumor progression.