nm23基因产物/NDPK在食管癌中的表达及其与淋巴结转移的关系

nm23 gene Product/NDPK Expression and Its Correlation with Lymph Node Metastasis in Esophageal Carcinoma

应用免疫组化S－P方法，研究100例食管癌手术标本中nm23基因产物／NDPK的表达及其与淋巴结转移的关系。结果显示：食管癌原发灶中NDPK的阳性表达率随着食管癌浸润深度的进展逐渐下降，当肿瘤浸润全层时，阳性表达率明显低于浸润粘膜及粘膜下层者，两者差异有显著意义（P＜0．01）；无淋巴结转移者与有淋巴结转移者其阳性率差异具有显著性意义（P＜0．01）。

The expression of nm23 gene product/DNPK was examined immunohistochemically in resected human esophageal carcinomas using anti-NDPK polyclonal antibody. Of the 100 carcinomas tested, 68% showed positive staining of nm23/NDPK in the primary lesious. Inverse relationships was found nm23/DNPK expression and tumor invasion(P<0.01). In patients without lymph metastasis, the positive staining rate was significantly higher than in those with metastasis.