血清AFP与AFU联合检测诊断原发性肝细胞癌

The value of Determination of Alpha-Fetoprotein and Alpha-L-Fucosidase in the Diagnosis of Primary Hepatocellular Carcinoma

对原发性肝细胞癌（PHC）、肝炎肝硬化及其它各种恶性肿瘤患者共419例进行血清a-L-岩藻糖苷酶（AFU）和甲胎蛋白（AFP）的测定，并以60名健康人作对照，结果PHC组的AFU活性（241．9±112．5）显著高于健康对照组（116．1±28．0）及其他各组（P＜0．01），AFU活性对PHC诊断的敏感性为69．6％，特异性为90．1％，AFU活性与AFP浓度间无明显相关性，AFP与AFU联合检测对PHC的诊断率可提高到89．6％，且随病情好转和恶化而下降和上升，提示检测血清AFU活性对PHC的诊断、疗效观察均有重要的临床价值。

The serum levels of Alpha-Fetoprotein(AFP) and Alpha-L-Fucosidase (AFU) were determined in 240 patients with Primary Hepatocellular Carcinoma (PHC), 91 patients with digestive tract cancers, 41 patients with other malignant neoplasms and 60 healthy subjects. The result showed that the serum AFU activity in patients with PHC (241. 9±112. 5 ) was significantly higher than in control (116.1±28.0)and other patients (P <0.01). AFU sensitivity and specificity were 69.6% and90.1%, respectively. There was not significant correlatively of the AFU activity and the level of AFP in the serum. Throuth combination of AFU and AFP assay,the diagniostic positively in PHC could be raised to 89. 6%. Marked decreases or increase of AFU levels followed patient's condition that was improved or got worse after surgical resection or chemotherapy. In consequence, the method of determination of serum AFU act1vity was clinically valuable in the diagnosis, observation of treatment efect in PHC.