青蒿素对BGC-823癌细胞生长 转移及侵袭能力的影响

Effects of Artemisinin on Growth Invasion and Metastasis of BGC-823 Cancer Cell

目的:研究青蒿素对人胃癌细胞株BGC-823的生长、侵袭和趋化运动能力的影响。方法:采用细胞培养,transwell小室法和冲刷实验,观察不同浓度青蒿素对BGC-823细胞株生长侵袭、黏附和趋化运动能力的改变。结果:青蒿素在浓度≥10μmol/L时可显著抑制BGC-823细胞的生长,并表现出剂量和时间依赖效应(>2d,P<0.01),同时青蒿素可显著降低BGC-823细胞的侵袭、黏附和趋化运动能力(P<0.01)。结论:青蒿素对人胃癌细胞株BGC-823的生长、侵袭和趋化运动能力有显著抑制作用,有可能成为胃癌的临床治疗的一种方法。

Objective：To study the effect of artemisinin on growth , invasion and metastasis of BGC - 823 cancer cell. Methods： Cell culture, transwell chambers and wash way were used to detect the difference of growth, invasion and metastasis ability of BGC - 823 cancer cell between control group and artemisinin group. Results：Different concentrations of artemisinin could significant suppress growth of BGC - 823 cancer cell in a dose dependent（/〉 10 μmol/L, P 〈 0.01） and time dependent（ 〉 2 d, P 〈 0.01）, and artemisinin could significant suppress invasion and metastasis ability of BGC - 823 cancer cell（ P 〈 0.01 ）. Conclusion： Artemisinin could significant suppress the growth, invasion and metastasis ability of BGC - 823 cancer cell. It suggests that artemisinin may be an ideal drug for gastric cancer therapy after a series of preelinlic and elinlic researches.