神经断端肌内埋入防治残端神经瘤的实验研究

EXPERIMENTAL STUDY ON PREVENTION AND TREATMENT OF NEUROMA BY IMPLANTING NERVE STUMP INTO MUSCLE

周围神经切断端发生神经瘤是周围神经损伤的常见并发症，约１０％患者有顽固性疼痛。为研究神经断端肌内埋入防治残端神经瘤的机理，选用ＳＤ大白鼠１６只，将双侧坐骨神经切断后，左侧神经断端肌内埋入为实验侧，右侧神经断端自然回缩不作处理为对照侧，运用组织学和电生理学检测。结果表明，对照侧的神经近端在术后１个月就有神经瘤形成，而实验侧其神经断端的神经纤维分散长入肌纤维间，无明确的神经瘤形成。说明，神经断端肌内埋入可以防治残端神经瘤形成。

Prevention and treatment of traumatic neuroma by implanting the proximal neural stump into the muscle were studied. Sixteen SD rats were used for the experimental study. The proximal stump of the left sciatic nerve was implanted into the nearby muscle as the experiment side, whereas the proximal stump of the right sciatic nerve was left untreated as the control side. The results were assessed with histological and electrophysiological methods. The experiment demonstrated that neuroma was formed in the control side one month postoperatively, whereas in the experimental side the nerve fibers were dispersed among the muscle fibers and no definite neuroma was formed. Implantation of neural stump into muscle could prevent and treat traumatic neuroma.