^(99m)Tc标记抗CA15-3 McAb乳腺癌放免显像初步临床研究

Preliminary clinical application of radioimmunoimaging of breast carcinoma using 99m Tc labeled anti CA15 3 monoclonal antibody MACA1

为评价９９ｍＴｃ标记抗ＣＡ１５３单克隆抗体（ＭｃＡｂ）ＭＡＣＡ１放射免疫显像（ＲＩＩ）诊断乳腺癌的临床价值，对７例乳腺肿瘤患者进行ＲＩ，并测定标记ＭｃＡｂ血液半清除时间（Ｔ１／２）和生物学分布。结果：３例原发性乳腺癌和１例右侧乳腺癌根治术５年后右腋窝淋巴结转移者，ＲＩ阳性；１例左侧原发性乳腺癌伴左腋窝淋巴结转移者，ＲＩＩ假阴性；１例右侧乳腺癌根治术７年后常规随访和１例左侧乳腺小叶增生者，ＲＩ阴性。标记ＭｃＡｂ血液Ｔ１／２：快相为０７８±０３０小时，慢相为１９９０±３７５小时。全身显像示标记ＭｃＡｂ主要通过肝、肾清除。因此，９９ｍＴｃＭＡＣＡ１ＲＩＩ可作为乳腺癌诊断的重要辅助手段，对术后复发、淋巴结转移等具有一定的诊断价值。

PURPOSE To evaluate the clinical diagnostic value of radioimmunoimaging (RII) in breast carcinoma. METHODS 7 patients with breast tumors were imaged by RII using 99m Tc labeled anti CA15 3 monoclonal antibody MACA1. The clearance of the radiolabeled antibody in blood (half time, T 1/2 ) and the biodistribution were studied. RESULTS RII was positive in 3 patients with primary breast carcinoma and one patient with lymph node metastases in right sided axilla who received right sided mastectomy 5 yrs ago due to breast carcinoma. Tumors were not detected by RII in one case with left sided primary breast carcinoma accompanied by unilateral axilla lymph node metastases. RII of the remaining 2 patients were negative, including one case with mammary adenoproliferation and the other of follow up patient who underwent right sided mastectomy 7 years ago due to breast carcinoma. Blood radioactivity decreased with T 1/2α of 0 78±0 30h and T 1/2β of 19 90±3 75h. The radiolabeled antibody was excreted mainly through liver and kidney showed by whole body images. CONCLUSIONS RII using 99m Tc labeled MACA1 may be applied as a valuable method in the diagnosis of primary breast carcinoma, recurrence and lymph node matastases.