补肾壮阳口服液的急性及长期毒性研究

A STUDY ON THE ACUTE AND CHRONIC TOXICITY OF BU-SHEN ZHUANG-YANG(RENAL TONIC) ORAL LIQUOR

补肾壮阳液急性毒性实验，口服最大耐受量为４０ｇ／ｋｇ．未见毒性症状。大鼠长期毒性实验灌胃给药２０ｇｌ／Ｋｇ、１０ｇ／ｌＫｇ和Ｓｇ／ｋｇ，连续４周，各组无动物死亡，动物外观、休重增长，血象、肝骨功能及各脏器指数与对照组无异。病捡报告高剂士组有３只大鼠部分肝细胞胞浆疏松化和气球样变，但留存动物停药１０ｄ后，病检均正常。提示补肾壮阳液临床口服用药安全范围较大。

TheThe acute and chronic toxicity of Bu-shen Zhuang- yang (Renal Tonic) Oral Liquor Was studied. The tolerance dose for acute toxicity in Kunming mice was 40 g/kg while the chronic toxicity tests were carried out in SD rats with the dosages of 20 g/kg, 10g/kg, and 5 g/ky respectively. No deaths were found and little pathological changes were noticed in the organs of all the animals except certain loose cytoplasmic changes in some hepatic cells in 3 rats of the high dosage group. No changes were detected in the routine blood tests, the tests on creatinine and nitrogen of urea in the blood 14 and 28 days after administration. 10 days after the discontinuation of the experiment,all the tests showed normal results in the tested animals. The study suggested that a considerable safety for the clinical administration of Bu ─shen Zhuang ─ yang ( Renal Tonic) Oral Liquor.