痤疮宝口服液的急性及长期毒性研究

THE STUDY OF THE ACUTE AND CHRONIC TOXICITY OF ZUO-CHUANG-BAO ORAL SOLUTION

痤疮宝口服液急性毒性试验，昆明种小鼠口服给药最大耐受量为178．4g／kg，未见明显毒副作用。长期毒性试验，大鼠按33．9g／kg·d，1784g／kg．d的剂量连续给药4周，各组无动物死亡，动物外观、体重增长、血象、肝肾功能又脏器指数与对照组比较无异常。病理报告高、低剂量组与对照组比较，对胃肠粘膜有一定毒性作用，停药2周后再查，病检正常，提示此种毒性作用是可逆的。

The tolerant dose of Zuo-Chuang-Bao oral Solution glven to Kunming mice was 178. 4g/kg in us acute and chronic test and no obuious toxic side effect was found in lts long -term Chronic test while the Tats were given the dose of 33. 9g/kg. d,17.84g/kg. d continuously for 4 weeks and no death was found and little pathological changes were noticed in the physical appearance and weight, the blood test, the hepatic and renal of function, vzscera index of the mice, compared with those of the control group.According to the comparison of the pathology report between the tested and control group, it has some toxic effect on gastrzc and enteric mucosa. However 2 weeks after the discontznuation of the oral solution, normal results were noticed in the pathological examination in the tested mice, whtch suggested that such toxicity is reversible.