摘要
27例类风湿关节炎(RA)病人连续七年服用MTX7.5mg/w,其临床症状和免疫学指标与治疗前相比均有显著的改善,P<0.001,表明MTX治疗RA能维持长期的疗效。长期服用MTX时主要的毒副反应是感染,本资料观察到1例肺结核和1例丹毒,另有2例肺炎未能完成7年疗程。本组病人未发现国外报道的其它副反应,这可能由于使用了较低的MTX剂量。
Twenty-seven patients with rheumatoid arthritis (RA) were consecutively treated with weekly pulse oral methotrexate (MTX) at a dosage of 7.5mg/week for 7 years to examine the long-term efficacy and safety of the medicine. This was the extension of author's previous two-year follow-up. A significant improvement was still demonstrated in their clinical symptoms and immunologic parameters. Infection was commonly noted to be the major factor limiting long-term MTX administration. During the present study 2 patients experienced pulmonary tuberculosis and erysipelas respectively. In addition, 2 patients suffered MTX pneumonitis, discontinued MTX therapy and withdrew from the study. Other MTX toxic effects reported previously in the literature were not observed. It might be attributed to the lower dosage of MTX used in his study.
