摘要
采用高效液相色谱(HPLC)法检测系统性红斑狼疮(SLE)患者尿新蝶呤(NP)浓度。31例为健康对照组,41例为病例观察组。其中SLE26例(活动期SLE16例,非活动期SLE10例)、非SLE15例(其他结缔组织病6例,慢性肾病9例),检测尿NP水平均较健康对照组高,以活动期SLE最高,(P<0.001)。经激素、免疫抑制剂等治疗后,尿NP随临床症状改善而下降。本研究表明:在SLE患者中检测尿NP,对随访SLE活动以及了解当时的肾脏病理过程有一定的临床意义。可作为一种监测临床疗效且无创伤的敏感方法。
The concentration of urinary neopterin (NP) was assayed by the method of HPLC in 41 patients and 31 normal subjects as control group. The patients consisted of 26 cases of SLE (active SLE 16 cases and inactive SLE 10) and 15 cases of non-SLE (other connective tissue disease 6 and chronic nephrosis 9). The average concentration of urinary neopterin in the observed group was higher than that of the normal control group and the highest concentration appeared in patients with active SLE (P< 0.001). After treatment with steroids and immunosuppressant the concentration of urinary neopterin decreased along with improvement of the clinlical symptom. This study shows that NP/Cr in urine of the patients with SLE is not only a sensitive method monitoring clinical curative effect but also a no invasive method.
关键词
系统性
红斑狼疮
尿
新蝶呤
lupus erythematosus systemic urine neopterin
