摘要
为了解韦格纳肉芽肿这一特殊血管炎的临床特征,分析了1983年～1995年16例住院患者,发现最常受累的器官为上呼吸道、肺和肾脏,受累率分别为87.6％、87.5％、81.2％。11例病人有病理诊断,病理标本的阳性率肾>鼻粘膜>支气管粘膜。该病易误诊,预后差。糖皮质激素和环磷酰胺联合治疗可降低致残率和病死率。
To know the clinical features, the treatment and prognosis of Wegner's granulomatosis (WG), 16 inpatients with WG from 1983 to 1995 were analyzed. The most common involved systems are upper respiratory tract (87. 5% ), lung (87. 5% ), and kidney (81. 2% ). Eleven patients had pathological evidence. The specimen of kidney is more valuable than the mucous membrane of nose and bronchus. Five patients were dead after hospitalization, 4 of them were relative to the disease activity without immunosuppressive agent. The combination of glucocorticosteroid and cyclophosphamide may reduce the mortality and morbidity.
