摘要
利用病例对照调查法观察与中老年人手OA相关的危险因素,发现与主食种类有关,面粉(OR=3.02)、玉米面(OR=2.41)与大米(OR=0.30)相比,是OA的危险因素。采用前瞻性角度,对三种主食类型农村居民的手OA发病水平进行了调查,证明了主食中T-2毒素含量与居民典型OA检出量之间存在“剂量效应”联系。将T-2毒素按雏鸡体重每公斤100μg计算掺入正常饲料,喂养5周,发现18只中16只雏鸡膝关节软骨出现明显退行性病变,实验还发现,T-2毒素对雏鸡的软骨组织DNA、蛋白质合成有明显抑制作用。据此认为,T-2毒素有可能成为OA发生的致病因子之一。
The cross-sectional association between radiographic osteoarthrosis (OA) of the hand and a variety of risk factors was studied. It was found by the statistical analysis of logistic regression that different kinds of staple foods were related to OA (i.e. wheat flour, OR = 3.02; maize flour, OR = 2. 41; rice, OR= 0.30). T-2 toxin content in the grain associated with the hand osteoarthrosis of farmers living in different types of staple foods' areas was investigated. It was concluded that T-2 toxin content of staple food had a definite 'dose-effect' relationship with the prevalence rate of typical OA(≥10 scores) based on prospective study. One-day-age chickens were fed on the diet containing 100μg T-2 toxin per 1 kg weight daily until they were killed at fifth week, and it was found that 16/18 presented early retrograde affection in growth plate of knee joint. Biological experiments show that T-2 toxin has abvious inhibitory effects on synthesis of protein and DNA in cartilage tissues. Therefore, the T-2 toxin produced by Fusarium in the grain is one of the pathogenic agents of OA.
