摘要
为提高对Paget病诊断的认识,报告7例骨Paget病,其中5例有骨和关节的疼痛,2例分别为肾结石、骨关节炎就诊时偶发,骨侵犯的部位以头、脊柱、骨盆、四肢长骨最为常见,血碱性磷酸酶(AKP)7例皆显著升高。X线片和核素(99mTc)扫描(ECT)7例患者皆有不同部位的骨密度增高及核素摄取增加区,1例头颅X线片呈穿凿样改变和颅骨增厚。对骨关节疼痛特别是中年以上的患者,X线和ECT检查异常结合血AKP和尿HP升高,对提高骨Paget病的诊断率有很大的帮助。降钙素和二磷酸盐是常用的治疗药。
Seven patients with Paget's disease of bone were reported. Bone and joint pain is the most common clinical manifestations (5 cases) . However, it was also occasionally found that some patients were without pain at the early periods of disease. The serum AKP increased obviously and the serum calcium level was normal in all patients. Uric hydroxyproline (HP)of 4 patients was increased. Bone sites involved usually oc-cured in head, spine, pelvis, and long bone of limbs. X-ray film showed different os-teosclerotic areas and increasing absorption of 99mTc by emission computed tomography (ECT) in all patients. One skull X-ray film demonstrated radiolucency areas and bone thickening. Therefore, to make early diagnosis of Paget's disease of bone, both X-ray and ECT abnormalities combined with serum AKP and uric HP increasing are greatly helpful. Calcitonin and diphosphonate are often used to treat this disease.
