非小细胞肺癌中CDK4I/P^(16)的表达及其临床意义

Clinical Significance of CDK41/P^16 Expression in Human Non-small Cell Lung Cancer

目的；探讨Ｐ~16基因产物在人非小细胞肺癌中的表达及其临床意义。方法：采用免疫组化法检测８３例人非小细胞肺癌组织中Ｐ~16基因产物的表达，并以２０例正常肺组织作对照。结果：肺癌中Ｐ~16表达水平（６５.９３％）明显低于正常肺组织（８８．２４％）（Ｐ＜０．０１）。Ｐ~16表达水平降低的程度与肺癌细胞分化程度，原发肿瘤大小和肺癌转移有密切关系（Ｐ＜０．０１或Ｐ＜０．０５），而与肺癌病期、组织学类型、肿瘤部位和患者年龄均无明显关系（Ｐ＞０．０５）。结论：Ｐ~16基因可能参与人非小细胞肺癌的发生、细胞的分化、发展和转移过程。

Objective To explore the clinical significance of P^16 gene product expression in human non small cell lung cancer. Methods. Expression level of P^16 gene product was detected in 83 non - small cell lung cancer samples and 20 normal lung tissues as control by immunohistochemistry. Results The expression level in lung cancer(65. 92 % )was significantly lower than that in control group (88. 24% ) (P<0. 01) The degree of decreased expression of P^16 gene product in lung cancer was closely related to cell differentiation of the tumor,size of the primary tumor and metastasis of the cancer(P<0. 01 or P<O. 05),but not to stages of the tumor,histological classification of tumor,location of the cancer,and ages of the patients (P > 0. 05). Conclusion p^16 gene may be involved in the oncogenesis,development,and metastasis of human non-small cell lung cancer.