维拉帕米对先天性心脏病右室心钠素的影响

Atrial natriuretic factor levels in patients with congenital heart disease:affected by verapamil

在２２例先天性心脏病患儿（ＣＨＤ）行右心导管检查中，通过检测应用维拉帕米（ＶＰ）前后的右室血浆心钠素（ＡＮＦ）浓度和血流动力学变化。结果显示：①应用ＶＰ前ＡＮＦ与平均肺动脉压（ｍＰＡＰ）明显正相关；②应用ＶＰ后伴肺动脉高压（ＰＡＨ）的ＣＨＤ患儿ＡＮＦ浓度与ｍＰＡＰ均明显降低；而肺动脉压正常患儿无明显变化。③ＶＰ对平均右房压，平均右室压和平均心率均无影响。本文提示钙拮抗剂——维拉帕米可降低ＣＨＤ伴ＰＡＨ患者的ｍＰＡＰ和右室ＡＮＦ水平。

The effects of verapmil(VP)on right ventricular plasma levels of atrial natriuretic factor (ANF)were studied in 22 children with congenital heart disease during catheterization.The results showed that the levels of ANF and mPAP were decreased in patients with PAH and unchanged in patients with normal PAP by VP.There wasa significant correlation between the levels of ANF and mPAP at the baseline.However,VP did not affect the mRAP.mRVP and mHR in patients with congenital heart diseases.Our data indicate that calcium channel blockers may reduce plasma ANF levels in patients with congenital heart disease,especially for those with PAH.