偏头痛患者血浆降钙素基因相关肽和P物质含量的变化及其与发病机制关系的探讨

CHANGES IN THE PLASMA CONCENTRATION OF CALCITONIN GENE-RELATED PEPTIDE AND SUBSTANCE P IN MIRINE HEADACHE PATIENTS AND ITS RELATION WITH PATHOGENESIS

采用放免分析（RIA）法，测定了偏头痛发作期26例，间歇期23例患者及正常对照20例颈外静脉及肘静脉血中降钙素基因相关肽（CGRP）和P物质（SP）含量。观察了英明格对国人偏头痛的疗效，测定并对比了英明格治疗前、后颈外静脉（EJV）血中CGRP和SP含量，结果显示：（1）偏头痛发作期EJV血中CGRP和SP含量显著性升高，而在肘静脉血中不升高。（2）头痛缓解后，EJV血中CGRP和SP含量降至正常水平。（3）英明格对国人也是止痛迅速，安全度高的治疗偏头痛发作的药物。

Plasma concentration of calcitonin gene-related peptide (CGRP) and substance P (SP) were measured by radio-immuno assay (RIA) in 49 migraine patients during migraine attack (n= 26) or remitent period and in 20 blood donors without headsches. Blnd was taken both from external jugular vein (EJV) and from cubital vein (CV) in the same person.Twelve petients during migraine attack were tteated with sumatriptu. The therapeutic effect was correlated with the changds in plasma concentration of CGRP and SP. The results showed that: (1) There is a significant increase of plasm CGRP and SP concentration in migraine attack patients in blnd taken from EJV but not ftom CV; (2) The EJV plasma concentration of CGRP and SP returned to normal level when the attuck was over; (3)Sumatriptun showed a rapid therapeutic efficacy in Chinese migraine potients without significant side effects.