神经损伤性痛觉过敏以及不同时间间隔的电针对痛觉过敏的调整作用

EXPERIMENTAL NEUROPATHIC HYPERALGESIA AND ITS TREATMENT BY ELECTRO-ACUPUNCTURE WITH VARIOUS INTERVALS

在动物自由活动状态下采用辐射热痛阈测定方法，观察了定时定量夹损坐骨神经干大鼠的痛觉改变（痛觉过敏）及不同间隔的电针对病觉过敏的调整作用。30只大鼠随机分为对照组、电针1组、电针2组和电针3组四组。用WQ－6F电针议产生的频率50Hz，强度1～1．5mA的电脉冲电针大鼠“阳陵泉”和“悬钟”穴。对照组大鼠不给予电针；电针1组大鼠每日电针一次；电针2组大鼠隔日电针一次；电针3组大鼠隔2日电针一次，各组电外均持续一个月。结果显示：定时定量夹伤一侧坐骨神经可引起同侧足底痛觉过敏，这种现象可持续17天，但对测足底的痛闻无明显改界；损伤后每日或隔日一次弱强度电针可减弱上述痛敏的发生，并促进其恢复；而每三天一次的电针不能减弱病敏的发生。说明在治疗神经损伤性疾病的电针参数选择中，针刺的间隔也是一个重要因素。

The regulatory effects of electro-acupuncture on thermal hyperalgesia in a peripheral mononeuropathy model were observed in rats. Peripheral mononeuropathy was induced in adult rats by crushing an unilateral common sciatic nerve with 50g in force lasting for 5 min at 4 points along the nerve. The postoperative plantar cutaneous hyperalgesic response to noxious radiant heat stimulation was measured by a newly developed thermal pain threshold detector in awake and unrestrained condition. The rats with crushed sciatic nerve were divided randomly into four groups: control, electro-acupuncture 1 (EA1). EA2 and EA3. In the 3 EA groups,the electrical pulses generated by a WQ-6F electronic apparatus with frequency of 50 Hz and intensity ranging from 1-1. 5 mA were delivered to Yanglingquan (GB34)and Xuanzhong (GB39) points. The rats in control were not stimulated by electro-uacupuncture,while those in EA1,EA2 and EA 3 groups were given electro acupunctre every 1, 2 and 3 days respectively. It was noticed that the unilateral injury of the sciatic nerve could induce thermal hyperalgesia in the affected hind paw. lasting for about half a month. The hyperalgesia could be relieved by electro- acupunctre given once every day or every other day but not every 3 days. The results indicate that in the treatment of hyperalgesia,the interval for applying acupuncture is an important factor determining its analgesic effects.