颈动脉粥样硬化与缺血性卒中的关系和相关因素研究

The study of relationship between carotid atherosclerosis and ischemic stroke and correlation factors

目的探讨颈动脉粥样硬化与缺血性卒中的关系以及颈动脉粥样硬化的相关危险因素。方法对86例缺血性卒中患者和88例对照者进行颈动脉彩色多普勒检查,测定颈总动脉内-中膜厚度(intima-media thickness,IMT),分析颈动脉粥样硬化与缺血性卒中的关系;根据颈总IMT将所有患者分为斑块组和无斑块组,比较两组超敏C反应蛋白(hs-CRP)、血脂水平,分析颈动脉粥样硬化的危险因素。结果(1)缺血性卒中组的hs-CRP、低密度脂蛋白胆固醇(LDL-C)和颈总IMT明显高于对照组。(2)斑块组的年龄、高血压、糖尿病患者和hs-CRP水平均明显高于无斑块组。结论颈总IMT、hs-CRP、LDL与缺血性卒中发生有关;hs-CRP是颈动脉粥样硬化的预测因子,它可能通过促进颈动脉粥样硬化影响缺血性卒中的发生。

Objective To investigate relationship between carotid atherosclerosis （CAS） and isehemic stroke and correlation factors. Methods 86 strokes and 88 age-matched control group were checked by color Doppler uhrasonography on the carotid arteries, the levels of IMT in the average of common carotid artery was observed, and relationship between carotid atherosclerosis （CAS） and ischemic stroke. All cases were divided into the plaque group and non-plaque group according to the ultrasonic presence and absence of plaque, and the risk factors were compared. Results Compared with the control group, a significantly increased level of serum high sensitivity C reactive protein （hs-CRP） and LDL, and thicker intima-media thickness （IMT） of carotid artery were found in the stroke group. Age, hypertension, diabetesand and hs-CRP levels were higher in the plaque group than those in the non-plaque group. Conclusion Carotid IMT, hs-CRP, and LDL might play important roles in ischemie stroke, it could be used to forecast the onset of CAS.