阿米卡星不同给药方法治疗细菌感染的成本效果分析

Cost-effectiveness analysis of Amikacin Injection with Different Dosage in the Treatment of Bacterial Infections

目的:观察阿米卡星相同日剂量2种不同给药方法对药物经济学的影响。方法:66例细菌感染患者采用阿米卡星0.4 g,ivd qd,随机分为A、B组,A组,4～8 mg·min^(-1),B组按经验,未规定单位时间给药量。结果:A组和B组药物血药浓度≤15.1μg·ml^(-1)分别有4例和22例;临床有效率为91.4%(32/35)和38.7%(12/31),成本-效果比(C/E)A组为4079,B组为9755。结论:A组比B组(按经验习惯性给药)治疗效果好,更经济。

Objective： To conduct a cost-effectiveness analysis of two different dosage regimens under same daily dose of Amikacin injections in treatment of bacterial infection. Method： A total of 66 patients with bacterial infection were assigned to receive Amikacin Injection 0.4 g q. d by intravenous drip, and 35 cases （group A） were randomly assigned to receive Amikacin 4 -8 mg.min^-1 and the control group to receive not stipulate unit give drug portion by time （group B, n = 31 ）. Result： The results showed blood concentration were below 15.1 μg. ml^-1 in A group （n = 4 ） and B group （22 patients）, The effective rate of Group A was 91.4% （32/35）and Group B was 38.7% （12/31）, respectively and the corresponding cost-effectiveness ration of which were 4079, 9755, respectively. Conclusion： Group A is more economical than Group B in the treatment of bacterial infection.