桥本甲状腺炎患者外周血白细胞性激素受体的改变及其意义

Changes of Sex Hormones and Sex Hormone Receptors in Hashimoto's Thyroiditis

应用放射配体结合法检测38例慢性淋巴细胞性甲状腺炎（桥本甲状腺炎）患者外周血白细胞雄激素受体（AR）及雌激素受体（ER）。同时用放射免疫分析检测血浆黄体生成素（LH）、卵泡刺激素（FSH）、睾酮（T）、雌二醇（E2）及T3、T4和TSH。结果表明桥本甲状腺炎患者LH、FSH、E2和T无明显改变；白细胞ER明显升高，AR无明显改变；ER／AR比值明显升高。以上结果提示ER及ER／AR比值的升高与桥本甲状腺炎的发生及发展有一定关联。

Specific binding capacity of androgen receptor(AR)and estrogen receptor(ER) in the peripheral leukocytes was measured by radioligand binding assays in 38 patients with Hashimoto's thyroiditis. The binding capacity of ER was 1401±386, 1197±327, 873±238 and 694±214 sites/cell in the child-bearing age women and menopause women with and without Hashimoto's thyroiditis, respectively, which was higher in patients than in controls(P<0.01).The binding capacity of AR was 501±136, 453±174, 596±215 and 503±206 sites/cell in above mentioned 4 groups, respectively, with no significant difference as compared with controls. The results suggest that the change of ER may be related with the development of Hashimoto's thyroiditis.