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原花青素抗肿瘤作用机制研究进展 被引量:33

Research Developments of Anti-carcinogenic Mechanism of Proanthocyanidins
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摘要 原花青素是由(+)-儿茶酚和(-)-表儿茶酸组成的低聚或多聚酚类化合物,具有抗氧化、清除自由基、抗炎和抗癌的生理活性。本文综述了原花青素在抗氧化和清除自由基、抗炎、调节信号转导、促进肿瘤细胞凋亡、细胞周期阻滞和抑制血管生成等方面抗癌机制的最新研究进展。 Proanthocyanidins are a class of phenolic oligomers or polymers that consisit of (+)-catechin and (-)-epicatechin. They have antioxidant, free radicals scavenging, antiinflammatory and anticancer activities. This paper summarized the latest research developments of anti-carcinogenic mechanism of proanthocyanidins about antioxidation, scavenging free radical, antiinflammatory activity, regulatory signal transduction, pro-apoptotic effect, cell cycle arrest and inhibition of angiogenesis.
出处 《食品科学》 EI CAS CSCD 北大核心 2008年第10期694-697,共4页 Food Science
基金 天津市科技攻关项目(08JCZDJC16600) 天津市重大科技攻关项目(06YFGZNC04200)
关键词 原花青素 抗氧化 抗癌 信号转导 细胞凋亡 proanthocyanidins antioxidant anticancer signal transduction apoptosis
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