GOR抗体与HCV感染的相关性研究

Association of Anti - GOR Antibodies and Hepatitis C Virus Infection

用人工合成的GOR肽与BSA交联后包被反应板，作为捕获抗原，建立了检测GOR抗体的间接ELISA。共检测临床各类病人278例，正常供血员48名。结果慢性丙肝患者抗GOR阳性检出率为60．0％（36／60），血透患者为43．6％（17／39），白血病患者为500％（6／12），甲亢患者为40．4％（19／47）。对抗ot）R抗体阳性的意义进行了分析。

Anti - GOR antibodies were measured by an indirect ELISA in which synthesized GOR peptides were conjugated with BSA and bound to microwell plate. Sera from 278 patients and 48 blood donors were tested. The positivity for anti - GOR was 60 % (36/60) in patients with chronic hepatitis C, 43. 6% (17/39 ) in hemodialysis patients, 50.0% (6/12 ) in leukemia and 40. 4% (19/47) in hyperthyroldism. Their anti - GOR levels were higher than those of normal controls. The data suggest that anti - GOR is closely related to HCV infection and is useful in its diagnosis.