慢性肝病患者外周血淋巴细胞亚群的变化

Change of Peripheral Blood Lymphocyte Subgroups in Chronic Liver Disease

本文采用流式细胞仪对51例慢性肝病患者外周血淋巴细胞亚群进行了测定。结果发现慢性活动性肝炎（CAH）、慢性迁延性肝炎（CPH）和肝炎后肝硬化（HC）患者与正常对照相比，NK数量明显增加（P＜0．01），CD4+和CD3+数量均明显降低（P＜0．01），CAH的CDS+数量明显增加（P＜0．01），且CD4+／CDS+比值明显下降（P＜0．01），HC的CD4+／CD8+比值也下降（P＜0．05）。NK与CD8+数量的变化规律为CAH＞HC＞CPH＞正常对照。CD4+、CD4+／CDS+变化规律为正常对照＞CPH＞HC＞CAH，提示淋巴细胞亚群的变化与肝细胞受损程度及疾病活动密切相关。

Peripheral blood lymphocyte subgroups were determined by flow cytofluorometry in 51 patients with chroonic liver disease.The percentage of natural killer cells (NK)was significantly increased in chronic active hepatitis (CAH),chronic persistent hepatitiis (CPH)andliver cirrhosis (HC)as compared with the normal control (P<0.01).Both CD3 and CD4 cells were obviously decrreased (P<0.01).While CD8 cells in CAh were significantly elevated (P<0.01),CD4/CD8 ratio was markedly lowered (P<0.01),CD4/CD8 ratio was also lowered in HC (P<0.05),.The change of NK and CD8 cells in various diseases was in the following descending order,CAH>HC>CPH>normals, while that of CD4 /CD8 ratio: normals >CPGH >HC >CAH,It is suggested that the change of lymphocyte subgroups is closely related with the exthent of liver cell injury and disease activity.