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N末端BNP前体对老年人不典型心力衰竭诊断价值 被引量：6

THE CLINICAL SIGNIFICANCE OF SERUM LEVELS OF NITROGEN TERMINAL BRAIN NATRIURETIC PEPTIDE(NT-BNP) IN THE DIAGNOSIS OF NON-TYPICAL HEART FAILURE
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摘要 目的研究血浆N末端BNP前体(NT-BNP)对老年人不典型心力衰竭病人心功能的诊断价值,并与心脏超声检查结果进行比较。方法对60例老年病人测定血浆NT-BNP浓度,并行超声心动图(UCG)检查,应用统计学方法分析各项指标之间的关系。结果慢性心力衰竭(CHF)组与非CHF组NT-BNP水平比较差异有显著性(t=13.19,P<0.001);以NT-BNP>450 ng/L为界值,NT-BNP诊断不典型心力衰竭灵敏度高于左室射血分数(u=4.22,P<0.01)。结论NT-BNP是CHF诊断和鉴别诊断有效的量化指标,且快速准确;与UCG相比,NT-BNP对老年人不典型心力衰竭的诊断灵敏度高,对CHF具有排除诊断优势。 Objective To find out the clinical value of serum level of nitrogen terminal brain natriuretic peptide （NT- BNP） in the diagnosis of old non-typical heart failure patients and its advantages compared with the ultrasonic cardiograph （UCG）. Methods Sixty patients received both NT-BNP test and echocardiography examination. A statistical analysis was used to analyze the relationship between these items. Results The serum levels of NT-BNP were significantly different between chronic heart failure （CHF） group and non-CHF group （t= 13.19,P〈0. 001）. NT-BNP had higher sensitivity than left ventricle ejection fraction （LVEF） when NT-BNP〉450 ng/L （u=4.22,P〈0.01）. Conclusion NT-BNP is a quantitative index in the diagnosis and differential diagnosis of CHF. Compared with UCG, NTBNP showed higher sensitivity and negative predictive value in the diagnosis of CHF.
作者 周珊珊 蔡智荣
机构地区 青岛大学医学院附属医院心内科
出处 《青岛大学医学院学报》 CAS 2008年第6期480-482,共3页 Acta Academiae Medicinae Qingdao Universitatis
关键词 利钠肽 脑 心力衰竭 老年人 诊断 Natriuretic peptide, brain Heart failure Aged Diagnosis
分类号 R541.61 [医药卫生—心血管疾病]
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参考文献9

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二级参考文献21

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共引文献11

同被引文献51

  • 1钱小顺,侯允天,薛桥,韩亚玲,刘雪红,刘建立,王士雯.1605例老年多器官功能衰竭的临床分析[J].中华老年多器官疾病杂志,2002,1(1):7-10. 被引量：128
  • 2陈玉成,刘兴斌,吕均,祝烨,梁玉佳,曾智.氨基末端脑钠素前体(NT-proBNP)在风心病合并心力衰竭患者中检测的临床意义[J].四川医学,2005,26(5):491-493. 被引量：1
  • 3陈铃,朱红枫.氨基末端脑钠尿肽激素原对小儿心功能的评估[J].中国妇幼健康研究,2006,17(3):202-205. 被引量：2
  • 4孙加源,施梦（综述）,李银平,白春学（审校）.中国多器官功能障碍综合征研究进展[J].中国危重病急救医学,2007,19(3):189-192. 被引量：17
  • 5Mir TS, Marohn S, Laer S,et al. Plasm concentrations of N - terminalpro - brain natriuretie peptide in control children from the neonatal to adolescent period and in children with congestive heartfailure[ J]. Pediatrics ,2002,110 (6) : E76.
  • 6Wieczorek SJ, Wu AH, Christenson R, et al. A rapid B -type natri- uretic peptide assay accurately diagnoses left ventricutar dysfunction and heart failure: a muhicenter evaluation [ J ]. Am Heart J ,2002,144 (5) :834 -839.
  • 7Cushing SD,Berliner JA, Valente AJ,et al. Minimally modified low density lipoprotein induces monocyte chemotactie protein 1 in human endothelial cells and smoth muscle cells[ J]. Proc Nail Acad Sci, 1990,87(13) :5134 -5138.
  • 8Oishi IY, Wakatsuki T, Nishikado A,et al. Circulating adhesion mole- cules and severity of coronary atherosclerosis[ J]. Coron Artery Dis, 2000,11(1) :77 -81.
  • 9I Maisela S, Krishnaswamy P, Nowak RM, et al. Rapid measurement of B - type natriuretic peptide in the emergency diagnosis of heart failure [J]. N Eng J Med,2002,347:161 -167.
  • 10Galis ZS, Sukhova GK, Lark MW, et al. Increased expression of ma- trix metalloproteinases and matrix degrading activity in vulnerable re- gions of human atheresclerotic plaqus[J]. J Clin Invest, 1994,94 (6) :2493 -2503.

引证文献6

二级引证文献25

青岛大学医学院学报
2008年 第6期

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