摘要
目的探讨孤立性纤维性肿瘤的临床病理特征、诊断和生物学特性。方法对孤立性纤维性肿瘤2例进行病理组织学和免疫组化观察,并复习相关文献。结果孤立性纤维性肿瘤有其独特的病理组织学结构特点,同一病例不同区域之间差别很大,肿瘤主要由呈无结构性增生的短梭形或卵圆形细胞组成,形成交替分布的半富细胞区和疏松细胞区,可见血管外皮瘤样结构,肿瘤细胞间血管丰富,管壁胶原纤维化。免疫组化显示CD34（＋）、CD99（＋）。结论孤立性纤维性肿瘤可发生于胸膜外其他部位,多数病例临床上呈良性经过,约10%～15%出现不典型性和恶性变。
Objective To investigate the clinicopathologic features, diagnosis, and bionomics of solitary fibrous tumor （SFT）. Methods Histology and immunohistochemistry of two solitary fibrous tumors were studied and related literature reviewed. Results SFT had its own unique histopathologic structure, showing a great difference in different regions in the same case. The tumor was mainly composed by non-struetural hyperplastic short-spindle or oval cells, distributing alternately among cell-cluster and cell-puff zone. Hemangiopericytoma-likc structure could be seen, with profuse blood vessels among the cells. Immunohistochemistry showed CD34 （＋）, and CD99 （＋）. Conclusion Solitary fibrous tumor can occur in extrathoraeic locations, most manifest a benign course clinically, with 10% --15% of them show atypical or malignant changes.
出处
《齐鲁医学杂志》
2008年第6期496-497,499,共3页
Medical Journal of Qilu
关键词
纤维瘤
免疫组织化学
诊断
Fibroma
Immunohistochemistry
Diagnosis
