幼儿乙型肝炎疫苗接种的免疫效果及免后抗-HBs动态水平研究

STUDY ON IMMUNE EFFECT AND ANTI HBs LEVEL AFTER HBV VACCINATION

经放射免疫法（ＲＩＡ）检测乙型肝炎（乙肝）标记全部阴性的３～４岁幼儿，随机分为接种，对照两组。接种组按０、１、６月程序接种乙肝血源疫苗３０、１０、１０μｇ３针。免后１、６、１２、２４、３６个月抗－ＨＢｓ阳性率分别为９５．６８％、９５．００％、９２．３１％、８７．５０％、和８５．４０％。接咱乙肝疫苗后随着时间的延长，血清抗－ＨＢｓ滴度呈下降趋势。免后３年乙肝疫苗保护率７９．５０％

219 children at the age of 3-4 years who were HBV marker negative by RIA were randomly divided into observed and controlled groups by the ratio of 3 to 1. The observed groupreceived 30-10-10μg HBV vaccine by a 0-1-6 month schedule.The anti-HBs positive rate was 95.68% in one month (T1) after vaccination.The anti-HBs posittive rate in children of controlled group was 8.77%.In T6,T12,T24,T36 after vaccination the anti-HBs positive rates of observed and controlled groups were 95.00%,92.31%,87.50%,85.40% and 10.53%,17.65%,21.6%, 21.75% respectively.The anti-HBs GMT were 233.64,191.63,167.44,71.11,68.96mIU/ml,respectively in T1,T6,T24,T36.There was no HBsAg positve within two years.In the third year,the HBsAg positive rate was 1.23% in the observed group ,and in the cntrolled group,the HBsAg positive rate was 6.0%,the protective rate was 79.50%.