脊髓灰质炎三价糖丸疫苗免疫持久性——9年随访观察

IMMUNE PERSISTENCE OF TRIVALFNT ORAL POLIO VACCINE——A NINE-YEAR FOLLOW-UP

观察了６９名儿童口服脊髓灰质炎三价糖丸疫苗（ＯＰＶ）的免疫持久性。基础免疫后４年（再免疫前）Ⅰ、Ⅱ、Ⅲ型中和抗体阳性率分别为９１０７％、９４６４％和９４６４％，几何平均滴度倒数（ＧＭＲＴ）分别为１１７９８、１４３９９和７９９３。４周岁再免疫后１个月Ⅰ、Ⅱ、Ⅲ型抗体ＧＭＲＴ分别升至９０４７８、９７４５４和４８７２７。基础免疫后１个月至基础免疫后６年，３个型≥１：１６的抗体保护滴度在９４６４％～１００％。基础免疫后第７、９年３个型≥１：１６的抗体平均保护滴度分别占９２８６％和７０２４％。

The immune persistence of trivalent oral polio vaccine was observed in 69 children Four years 1 Epidemic Prevention Station of Zhilemu League,Nei Mongol Autonomous Region,Tongliao City,028000 2 Epidemic Prevention Station of Kailu County,Nei Mongol Autonomous Region after basic immunization the neutralization antibody positive rates of polio Ⅰ,Ⅱ,Ⅲ were 91 07%,94 64% and GMRT were 117 98,143 99 and 99 93 respectively Revaccination to these children at 4 years of age was carried out One month after revaccination the GMRT of polio Ⅰ,Ⅱ,Ⅲ raised to 904 78,974 54 and 487 27 respectively The ≥1:16 protective antibody titer against polio Ⅰ,Ⅱ,Ⅲ after one month and six years of basic immunization was between 94 64%-100%,and the average protection fiters after seven and nine years were 92 86% and 7 24% respectively