期刊文献+

新型抗心绞痛药物雷诺嗪研究进展 被引量:2

Progress on A Novel Antianginal Agent Ranolazine
下载PDF
导出
摘要 心肌缺血通常导致一系列的代谢变化,通过改善缺血心肌的代谢和心肌功能,可治疗缺血性心脏病。论文对代谢性治疗药物雷诺嗪抗心绞痛的作用机制及临床应用进行综述。 Myocardial isehemia often leads to a series of metabolic changes. Metabolic management of myocardial ischemia may improve myocardial functions. Therefore,metabolic intervention is a valid approach to the treatment of ischemic heart diseases. The effects of an'anlianginal metabolic agent and their mechanisms of action and clinical application were discussed here.
出处 《动物医学进展》 CSCD 2008年第11期89-92,共4页 Progress In Veterinary Medicine
关键词 心肌缺血 心肌代谢 代谢性治疗药物 雷诺嗪 心绞痛 myocardial ischemia myocardial metabolism metabolic agent ranolazine angina
  • 相关文献

参考文献24

  • 1张首国,王林,彭涛.抗心绞痛药物构效关系的研究进展[J].国外医学(药学分册),2005,32(4):217-222. 被引量:2
  • 2苗佩宏,徐江平.新型抗心绞痛药物雷诺嗪的研究进展[J].国外医学(药学分册),2003,30(4):197-200. 被引量:17
  • 3杨学林,赵临襄.雷诺嗪(ranolazine)[J].中国药物化学杂志,2007,17(3):195-195. 被引量:1
  • 4Leea L, Horowitzb J,Michael F. Metabolic manipulation in iscbaemic heart disease, a novel approach to treatment[J]. Eur-Heart J,2004,25:634-641.
  • 5Kennedy J A,Kiosoglous A J, Murphy G A,et al. Effect of perhexiline and oxfenicine on myocardial function and metabolism during low-flow ischemia/reperfusion in the isolated tatheart[J].J Card-invasc Pharmacol, 2000,36 (6) : 794-801.
  • 6Grynberg A. Effectors of fatty acic oxidation reduction:promising new anti-ischaemic gaents[J].Curr Phatmt Des, 2005,11 (4) :489-509.
  • 7Timmis A D, Chaitman B R, Crager M. Effects of ranolazine on exercise tolerance and HbAlc in patients with chronic angina and diabetes[J]. Eur Heart J, 2006, 27(1):42-48.
  • 8Antzelevitch C, Belardinelli L, Zygmunt A C, et al. Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties[J].Circulation, 2004, 110(8):904-910.
  • 9Stonep H, Gratsianskyn A, Blokein A, et al. Antianginal efficacy of ranolazine when added to treatment with amlodipine:the ERICA (efficacy of ranolazine in chronic angina) trial[J].J Am Coll Cardiol, 2006,48 :566-575.
  • 10McCormack J G , Stanley W C,Wollf A A. Rnaolazine: a novel metabolic modulator for the treatment of anigna[J]. Gen Pharmacol, 1998,30(5):639-645.

二级参考文献46

  • 1Jun-huiZHU Xing-xiangWANG Jun-zhuCHEN Yun-pengSHANG Jian-huaZHU Xiao-gangGUO JianSUN.Effects of puerarin on number and activity of endothelial progenitor cells from peripheral blood[J].Acta Pharmacologica Sinica,2004,25(8):1045-1051. 被引量:16
  • 2Schofield RS, Hill JA. The uee of ranolazine in cardiovascular disease[J].Expert Opin Investig Drugs,2002,11(1):117-123
  • 3Wolff AA, Rotmensch HH.Metabolic approaches to the treatment of ischemic heart disease:the clinicians'perspective[J].heart Fail Rev,2002,7(2):187-203
  • 4McCormack JG, Barr RL.Ranolazine stimulates glucose oxidation in normoxic, ischemic, and reperfused ischemic rat hearts[J]. Circulation, 1996, 93(1):135- 142.
  • 5Clarke B, Wyatt KM, McCormack JG.Ranolazine increases active pyruvate dehydrogenase in perfused normoxic rat hearts: evidence for an indirect mechanism[J]. J Mol Cell Cardiol, 1996, 28(2):341-350.
  • 6Allen TJ,Chapman RA.Effects of ranolazine on L-type calcium channel currents in guinea-pig single wentricular myocytes[J].Br J Pharmacol,1996,118(2):249-254
  • 7Letienne R,Vie B,Puech A,et al.Evidence that ranolazine behaves as a weak β1-and β2-adrenoceptor antagonist in the cat cardiovascular system[J].Naunyn Schmiedebergs Arch Pharmacol,2001,363(4):464-471
  • 8Wang JX,Maruyama K,Murakami M,et al.Antianginal effects of ranolazine in various experimental models of angina[J].Arzneimittelforschung,1999,49(3):193-199
  • 9Sabbah HN,Chandler MP,Mishima T,et al.Ranolazine,a partial fatty acid oxidation(pFOX)inhibitor,improves left ventricular function in dogs with chronic heart failure[J].J Card Fail,2002,8(6):416-422
  • 10Chandler MP,Stanley WC,Morita H,et al.Short-sterm treatment with ranolazine improves mechanical effciency in dogs with chronic heart failure[J].Circ Res,2002,91(4):278-280

共引文献29

同被引文献9

引证文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部