摘要
目的探讨温胃舒胶囊治疗慢性胃炎的药理作用。方法采用试剂盒法观察温胃舒胶囊对模型大鼠血清NO、NOS活力的影响;观察温胃舒胶囊对脱氧胆酸钠所致实验性慢性胃炎大鼠胃液pH值,胃蛋白酶含量及胃的组织病理变化的影响;采用放免法测定温胃舒胶囊对模型大鼠血清胃泌素,胃粘膜PGE2含量的影响。结果温胃舒胶囊0.19、0.38、0.76g·kg-1三个剂量组血清NOS活力降低,0.38、0.76g·kg-1剂量组血清NO含量降低,与模型组比较有显著差异(P<0.05,P<0.01);0.76g·kg-1剂量组血清胃泌素含量明显升高,与模型组比较有显著差异(P<0.01);温胃舒胶囊0.19、0.38、0.76g·kg-1三个剂量组均能够降低胃液pH值;0.76g·kg-1剂量组能升高胃蛋白酶含量,减轻胃部组织的病理变化,与模型组比较有显著性差异(P<0.05);温胃舒胶囊0.76g·kg-1剂量组可以明显提高胃粘膜中PGE2含量,与模型组比较有显著性差异(P<0.05)。结论传统中药复方温胃舒胶囊对慢性胃炎有一定的治疗作用。
Objective To discuss the pharmacodynamic effect of Wenweishu capsules on treating chronic gastritis. Methods To observe the activity of NO,NOS in serum,and gastrin, PGE2 gastric mucosal, gastric juice pH, pepsin and pathologicalhistology of model rats treated with Wenweishu capsule on experimental chronic gastritis rats caused by deoxysodium cholate. Results Compared with model groups, Wenweishu capsule can depress energy of serum NOS in the three dosage of 0.19 g·g^-1 ,0.38 g·g^-1,0.76g·g^-1, while 0.38 g·g^-1 and 0.76 g·g^-1 could reduce the content of serum NO,respectively （P〈0.05, P〈 0.01）; 0.76 g·g^-1 could improve the content of serum gastrin （P〈0.01）; 0.19 g·g^-1, 0.38 g·g^-1,0.76 g·g^-1 can reduce pH of gastric juice, 0.76 g·g^-1 decrease the content ofpepsinum（P〈0.05）, 0.76 g·g^-1 could increase the content of gastric mucosal PGE2 （P〈0.05）. Conclusions This result has showed that Wenweishu capsule can treat chronic gastritis to some extent.
出处
《现代中药研究与实践》
CAS
2008年第5期29-34,共6页
Research and Practice on Chinese Medicines
