固有荧光癌症诊断仪对胃部病变的诊断价值

The valuation of laser induced autofluorescence spectroscopy diagnosing lesions in stomach

目的探索激光诱发固有荧光光谱诊断仪(IFS-I)对胃癌病变的诊断价值。方法胃镜下收集66例病例,共74个病灶的固有荧光光谱。将三种光谱特征与病理结果相对照,分析诊断方法的敏感度、特异度和准确率。结果三种光谱特征中符合任意1条即为阳性的诊断敏感度最高,可用于胃癌和良性增生性病变的普查。在(460±20)nm波长处荧光特征的诊断特异性最高,可用于胃癌的精查。结论激光诱发固有荧光光谱诊断仪在胃癌及癌前病变的普查和胃癌明确诊断方面具有较好的应用前景。

Objective To explore the valuation of laser induced autofluorescence spectroscopy（IFS-I） in the diagnosis of gastric cancer. Methods The autofluorescence spectra of 66 cases with 74 lesions were collected under gastroscopy. Combined with the pathology, the sensitivity, specificity and accuracy were analyzed among three spectra characteristics. Results The characteristic wavelength of lesion according with anyone of（400 ±20）nm,（460 ±20）nm and （670 ±20） nm could be served as the positive diagnostic standard. It could he used to screen gastric cancer and precancerous diseases as the highest sensitivity standard. The characteristic wavelength of lesion according with （460 ± 20） nm could be used to diagnosis gastric cancer and precancerous diseases as the highest specificity standard. Conclusion IFS-I has a promising clinical valuation in screening gastric cancer and precancerous diseases and diagnosing gastric cancer.